Skip to main content
. 2021 Oct 11;10(10):1591. doi: 10.3390/antiox10101591

Figure 1.

Figure 1

Effects of curcumin, carnosic acid and their combinations on the growth/viability of DU145 and PC-3 prostate cancer cells. (a,c) The Alamar Blue assay data obtained after 48 h of cell treatment with vehicle (DMSO) or the indicated concentrations of curcumin (CUR), carnosic acid (CA) and their combinations (CUR + CA). Values given in parentheses are concentrations (μM). Data are presented as mean ± SEM (n = 3). Statistically significant differences are indicated for CUR + CA vs. the sum of the effects of CUR and CA applied separately. * p < 0.05. (b) The Combination Index (CI) analysis of DU145 cell viability for the indicated CUR + CA (μM) combinations. The CI values are plotted against the levels of the fraction affected. (d) The Alamar Blue assay data demonstrating the effects of increasing concentrations of CA on DU145 and PC-3 cells treated with CUR at 5 µM or 7 µM. The values are derived from the data (mean ± SEM; n = 3) shown in panels (a,c). * p < 0.05; ** p < 0.01; *** p < 0.001 and **** p < 0.0001 vs. CUR alone (0 µM CA).