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Model of airway surface dehydration in COPD due to CFTR dysfunction. (A) In non-smokers, an adequate exchange of ions occurs due to the correct functioning of the CFTR protein, located in the apical membrane of the respiratory epithelium. (B) In smokers, cigarette smoke produces a dysfunction of the CFTR protein producing an alteration of ion transport, making the mucus dehydrated, reducing the periciliary layer, and therefore hindering the expulsion of secretions.
