Table 2.

Antifibrotic miRNAs involved in SSc pathogenesis.

miRNA	Expression	Tissue Specimen(s)	Target Gene(s)	Reference(s)
miR-145	Downregulated	Fibroblasts Skin	SMAD3	Zhu et al. [34]
miR-29b	Downregulated	Fibroblasts Skin	COL1A1	Zhu et al. [34]
miR-let-7a	Downregulated	Fibroblasts Skin Serum	Unknown	Makino et al. [74]
miR-29a	Downregulated	Fibroblasts Skin Bleomycin-treated mice skin samples	COL1A1 COL3A1 TAB1	Maurer et al. [75] Jafarinejad-Farsangi et al. [58] Ciechomska et al. [76]
miR-3606-3p	Downregulated	Fibroblasts Skin	TGFBR2	Shi et al. [73]
miR-18a	Downregulated	Fibroblasts	Unknown	Nakayama et al. [62]
miR-150	Downregulated	Fibroblasts	ITGB3	Honda et al. [77]
miR-30b	Downregulated	Skin Serum Experimental mouse model	Unknown	Tanaka et al. [78]
miR-135b	Downregulated	Fibroblasts Serum Monocytes	STAT6	O’Reilly et al. [79]
miR-16-5p	Downregulated	Fibroblasts Serum	NOTCH2	Yao et al. [84]

COL1A1: collagen type 1 alpha 1 chain; COL3A1: collagen type 3 alpha 1 chain; TAB1: transforming growth factor beta activated protein kinase 1; TGFBR2: transforming growth factor beta receptor 2.