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Kaplan–Meier analysis for time to the incidence of grade 2 diarrhea based on the cut-off values of AUC0–24 (823.5 ng·h/mL) and C0 (28.5 ng/mL) of afatinib. Kaplan–Meier curves for the incidence of grade 2 diarrhea in patients with (a) AUC0–24 of greater than or equal to 823.5 ng·h/mL (solid line) and less than 823.5 ng·h/mL (dotted line) and with (b) C0 of greater than or equal to 28.5 ng/mL (solid line) and less than 28.5 ng/mL (dotted line).
