Table 5.
Summary of potential biomarkers in gastric juice for gastric cancer screening and early diagnosis.
| Sample | Type | Biomarker | Patients | AUC (95% CI) | Sensitivity (%) | Specificity (%) | Ref. |
|---|---|---|---|---|---|---|---|
| Gastric Juice Biomarkers | |||||||
| Gastric juice | DNA | BARHL2 | 30 patients (10 healthy patients, 10 early GC, and 10 advanced GC) | 0.92 | 90.0 | 100.0 | [99] |
| Gastric juice | miRNA | miR-129-1-3p and miR-129-2-3p | 141 patients (47 healthy patients, 42 GC patients, 34 gastric ulcer patients, and 18 atrophic gastritis patients) | 0.66 | 68.70 | 71.90 | [100] |
| Gastric juice | miRNA | miR-421 | 141 patients (47 healthy patients, 42 GC patients, 34 gastric ulcer patients, and 18 atrophic gastritis patients) | 0.77 (0.68–0.85) | 71.40 | 71.70 | [101] |
| Gastric juice | miRNA | miR-21 | 141 patients (47 healthy patients, 42 GC patients, 34 gastric ulcer patients, and 18 atrophic gastritis patients) | 0.97 | 85.70 | 97.80 | [102] |
| Gastric juice | miRNA | miR-106a | 141 patients (47 healthy patients, 42 GC patients, 34 gastric ulcer patients, and 18 atrophic gastritis patients) | 0.87 | 73.80 | 89.30 | [102] |
| Gastric juice | miRNA | miR-133a | 204 patients (34 healthy patients, 62 GC patients, 32 atrophic gastritis, 36 gastric ulcer, and 40 superficial gastritis patients) | 0.91 (0.86–0.96) | 85.90 | 84.80 | [103] |
| Gastric juice | circRNA | circ_0014717 | 122 patients (38 healthy patients, 30 gastric ulcer patients, 15 CAG, and 39 GC patients) | - | - | - | [104] |
| Gastric juice | piRNA | piR-1245 | 132 patients (66 healthy patients and 66 GC patients) | 0.89 | 90.90 | 74.20 | [105] |
| Gastric juice | lncRNA | RMRP | 130 patients (45 healthy patients, 39 GC patients, 30 gastric ulcer patients, and 16 CAG patients) | 0.70 | 56.40 | 75.40 | [107] |
| Gastric juice | lncRNA | AA174084 | 130 patients (45 healthy patients, 39 GC patients, 30 gastric ulcer patients, and 16 CAG patients) | 0.85 (0.78–0.92) | 46.00 | 93.00 | [106] |
| Gastric juice | lncRNA | lncRNA-ABHD11-AS1 | 39 GC patients, 30 patients with gastric ulcers, 16 patients with atrophic gastritis, and 45 patients with normal mucosa/minimal gastritis | 0.65 (0.54–0.77) | 41.00 | 93.40 | [108] |
| Gastric juice | Protein | GP87 | 231 patients (80 healthy patients, 82 GC patients, 20 chronic superficial gastritis patients, 14 patients with ulcer, 32 CAG patients, and 3 patients with polyps) | - | GC: 86.30 CAG: 60.00 |
- | [87] |
GC, gastric cancer; CAG, chronic atrophic gastritis; AUC, area under the curve; Ref, reference; -, no data available.