Table 1.

Established and proposed therapeutic targets in canine MIUC.

Target	Drug
COX-1/ COX-2	Piroxicam, Meloxicam, Carprofen
COX-2	Firocoxib, Mavacoxib
COX- 5-LOX	Tepoxalin
DNA damage repair mechanisms	Cisplatin, Mitoxantrone, Doxorubicin
Microtubular proteins	Vinblastin
DNA synthesis	Gemcitabine
CCR4	Mogamulizumab
Survivin	EZN-3042
Pan- ErbB	Sapatinib
PDGFR, VEGFR, KIT, Flt3	SU11654
BRAF	Vemurafenib, Dabrafenib
Pan- RAF	LY3009120
MEK	Selumetinib, Trametinib
ERK	SCH772984
P-38	SB239063
JNK	SP600125
Nectin-4	rMV-SLAMblind