. 2021 Sep 29;10(10):1553. doi: 10.3390/antiox10101553

Table 4.

Clinical evidence of antioxidant activity of natural compounds.

Molecules	Human Subjects	Effects	Refs.
Catechins	Patients of AFB-positive pulmonary tuberculosis.	Decreased MDA concentration.	[127]
		Decreased the level of NO production.
		Significantly increased SOD.
		Significantly decreased catalase and GPx level.
		Significantly increased GSH.
		Significant decrease in SH level.
Catechin	Adult obese subjects	Increased the gene expression, and also SOD and GPX activity.	[131]
		Reduced the levels of GSH.
		Increased TAP and GSSG.
		Decreased lipid peroxides.
		Altered the expression of genes involved in redox.
Catechins	Healthy postmenopausal women	No impact on serum d-ROM concentrations and plasma H₂O_2.	[135]
Catechins	Healthy postmenopausal women	Elevated postprandial plasma TRX concentrations.	[135]
Quercetin	Athletes	Significantly increased plasma FRAP.	[134]
Quercetin	Athletes	Unaffected TEAC Plasma F2-isoprostane values and protein carbonyls.	[134]
Quercetin	Non-smoking patients with symptomatic sarcoidosis	Increased total plasma antioxidant capacity.	[129]
Quercetin	Non-smoking patients with symptomatic sarcoidosis	Decreased MDA concentration.	[129]
Quercetin	Healthy young	Decrease in GSSG levels.	[132]
		Improved GSH/GSSG ratio.
		Significantly decreased TBARs levels.
		No effect in erythrocytes CAT, GPx, SOD activities, and SOD/GPx ratio.
Ferulic acid	Subjects with hyperlipidemia	Decreased the oxidative stress biomarker, MDA.	[130]
Gallic acid	Type 2 diabetes patients	No impact on plasma MDA and FRAP.	[133]
Carvacrol	Asthmatic patients	Significantly decreased plasma level of NO²-.	[128]
Resveratrol	Adult obese subjects	Increased the gene expression, and also SOD and GPX activity.	[131]
		Reduced the levels of GSH and GSSG.
		Increased TAP.
		Decreased lipid peroxides.
		Altered the expression of genes involved in redox.