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. 2021 Oct 2;9(10):1378. doi: 10.3390/biomedicines9101378

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The figure depicts the regulation by LH and FSH of aromatase expression. Gonadotropins are involved in ovarian steroidogenesis through their intracellular mediators, which are strongly supposed to be inositols. Actually, LH signal involves principally theca cells, while FSH primarily acts on granulosa. DCI: D-chiro-inositol; FSH: Follicle-Stimulating Hormone; FSHR: Follicle-Stimulating Hormone Receptor; LH: Luteinizing Hormone; LHR: Luteinizing Hormone Receptor; MI: Myo-inositol.