Table 1.
The table summarizes the in vitro evidence existing on the molecular regulation by DCI and Pinitol of genes relevant in cancer progression. c-Src: Proto-oncogene tyrosine protein kinase Src; COX2: cyclooxygenase-2; DCI: D-chiro-inositol; MMP-9: matrix metalloprotease-9; Nf-κB: nuclear factor kappa-light-chain-enhancer of activated B cells; NOX4: NADPH oxidase 4; NRF2: nuclear-factor-erythroid-2-related Factor 2; TNF-α: tumor necrosis factor-α; VEGF: vascular endothelial growth factor.
| Upregulated Genes | Downregulated Genes | Downregulated Genes | ||
|---|---|---|---|---|
| DCI | NRF-2 | Integrin β3 | Pinitol | Integrin β3 |
| TNF-α | TNF-α | |||
| IL-6 | IL-8 | |||
| Leptin | NF-κB | |||
| NOX4 | c-Src | |||
| c-myc | ||||
| COX-2 | ||||
| Bcl-2 | ||||
| Bcl-xL | ||||
| VEGF | ||||
| MMP-9 |