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Evolutionary conservation of COMP protein around the position 453 (asparagine). Multiple sequence alignment of COMP protein sequences from different species was performed by Clustal Omega program. Residue in red (N) corresponds to the asparagine located at position 453 in the human protein (NP_000086.2). Percentage corresponds to global identity compared to the human COMP protein. Asterisk represents individuals genotyped for p.Asn453Ser COMP mutation.
