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(A) Schematic showing the domains in HMG family proteins. Abbreviations: AT, AT hook; C-tail, C-terminal acidic tail; NLS, nuclear localization sequence; NBD, nucleosomal binding domain; RD, regulatory domain; A box, HMG box A; and B box, HMG box B. (B) HMGB1/2 can bind to a myriad of DNA structures. The light blue cylinder represents a nucleosome, and the dark blue ovals represent HMGB1/2.
