ACDRP	amish complex disease research program
ALD	alcoholic liver disease
ALT	alanine aminotransferase
APOB	apolipoprotein B
APOC3	apolipoprotein C3
ATGL	adipose triglyceride lipase
AUROC	area under receiver operating characteristics
BMI	body mass index
CCl4	carbon tetrachloride CD36: cluster of differentiation 36
CDKI1A	cyclin dependent kinase inhibitor 1A
CGI-58	comparative gene identification-58
CPN1	carboxypeptidase n subunit 1
CRISPR/Cas9	clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9
CVD	cardiovascular disease
DAGs	diacylglycerols
DNL	de novo lipogenesis
ENPP1	ectonucleotide pyrophosphatase/phosphodiesterase1
ER	endothelial reticulum
EWAS	exome wide association studies
FATP5	fatty acid transport proteins
FFAs	free fatty acids
FGF	fibroblast growth factor
FGFR4	fibroblast growth factor receptor 4
FNDC5	fibronectin type III domain-containing protein 5
FOXO1	forkhead box protein O1
GCKR	glucokinase regulator
GGT	γ-glutamyl transferase
GPR55G	protein-coupled receptor 55
GWAS	genome-wide association study
HCC	hepatocellular carcinoma
HFD	high-fat diet
HNRNPUL1	heterogeneous nuclear ribonucleoprotein U like 1
HSCs	hepatic stellate cells
HSD17B13	hydroxysteroid 17-β dehydrogenase 13
IFNL3/4	interferon λ3/λ4
IL28	interleukin 28
InsR	insulin receptor
iPSCs	pluripotent stem cells
IR	insulin resistance
IRAS	Insulin Resistance Atherosclerosis Study
IRS1	insulin receptor substrate
KLB	β-Klotho
KLF6	krueppel-like factor 6
KI	knock-in
KO	knock-out
LAL	lysosomal acid lipase
LD	lipid droplet
LDL	low-density lipoprotein
LIPA	lysosomal acid lipase
LPIAT1	lyso-phosphatidylinositol (Lyso-PI) acyl-transferase1
LPIN1	Lipin1
LPL	lipoprotein lipase
LYPLAL1	lysophospholipase-like 1
MARC1	amidoxime-reducing component 1
MBOAT7	membrane bound o-acyltransferase domain-containing 7
MCD	methionine choline deficient
MERTK	macrophage c-mer tyrosine kinase
MRI-PDFF	magnetic resonance imaging proton-density fat fraction
MTTP	microsomal triglyceride transfer protein
NAD	nicotinamide adenine dinucleotide
NAFLD	nonalcoholic fatty liver disease
NASH	nonalcoholic steatohepatitis
NOMAS	Northern Manhattan Study
OR	odd ratio
PCs	phosphatidylcholines
PCSK7	proprotein convertase subtilisin/kexin type 7
PCSK9	proprotein convertase subtilisin/kexin type 9
PI	phosphatidylinositol
PI3K	Phosphoinositide 3-kinase
PLIN2	perilipin 2
PLIN5	perilipin 5
PNPLA2	patatin-like phospholipase domain-containing 2
PNPLA3	patatin-like phospholipase domain-containing 3
PPP1R3B	protein phosphatase 1 regulatory subunit 3B
PROTAC	proteolysis-targeting chimera
PRSs	polygenic risk scores
PS	phosphatidylserine
PUFAs	polyunsaturated fatty acids
ROC	receiver operating characteristics
ROS	reactive oxygen species
SIRTs	sirtuins
SNP	single nucleotide polymorphism
SOD2	superoxide dismutase 2
SREBP1c	sterol regulatory element-binding protein 1
T2D	type 2 diabetes
TERT	telomerase reverse transcriptase
TG	triglyceride
TGF-β	transforming growth factor β
TLR4	toll like receptor 4
TM6SF2	transmembrane 6 superfamily member 2
TMC4	transmembrane channel like 4
TNF-α	tumor necrosis factor α
TRIB	tribbles homolog1
UCP	uncoupling protein
VLDL	very-low density lipoproteins