Mean values and standard deviation (relative expression) of microRNA (miR) expression in plasma samples of non-LC controls (white bars), LC-only patients (grey bars), and LC-COPD patients (black bars). Statistical analyses were performed separately for each study group of subjects. The letters a,b,c indicate the statistical significance: the same letter indicate no statistically significant difference among the groups for a given microRNA. In each study group, the expression levels of the study microRNAs did not differ among them if they shared the same letter. Different letters reflect different levels of expression for each study group.