Table 3.

Bivariate analysis of clinical and biological variables in patients with LC with and without COPD.

	LC-Only	LC-COPD	p Value
Smoking history
Never smokers, N (%)	12 (38)	4 (4)	<0.001
Ex-smokers, N (%)	9 (28)	48 (53)	0.023
Current smokers, N (%)	11 (34)	39 (43)	0.414
Packs-year, $\overline{\mathrm{x}}$ (SD)	46 (15)	58 (21)	0.015
FEV1, %, $\overline{\mathrm{x}}$ (SD)	94 (15)	62 (14)	<0.001
FEV1/FVC, $\overline{\mathrm{x}}$ (SD)	78 (6)	61 (9)	<0.001
DLCO, %, $\overline{\mathrm{x}}$ (SD)	82 (19)	68 (19)	0.001
Albumin, $\overline{\mathrm{x}}$ (SD)	4.4 (0.9)	4.0 (0.6)	0.016
miR-210, $\overline{\mathrm{x}}$ (SD)	207.13 (393.11)	45.95 (78.07)	0.006
MDA-protein adducts, $\overline{\mathrm{x}}$ (SD)	51.52 (18.53)	74.20 (37.97)	0.033
GSH, $\overline{\mathrm{x}}$ (SD)	12.54 (6.17)	6.97 (1.24)	0.001

Values are expressed as mean (standard deviation). Abbreviations: N, number of patients; FEV₁, forced expiratory volume in one second; FVC, forced vital capacity; DLco, carbon monoxide transfer; MDA-protein adducts, malondialdehyde-protein adducts; GSH, reduced glutathione.