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Local endothelium damage originating from the infected implants. (A) Purulent secretions at the implantation site after 48 h with 5 × 106 CFU (colony forming units) infected implant. (B) Histological staining with Masson Trichrome after 24 h, bars 50 µm. Gene expression of (C) vascular endothelial growth factor A (VEGF) and (D) Intercellular Adhesion Molecule 1 (ICAM) after 6 h, 24 h and 48 h, *: p < 0.05.
