ECSW therapy markedly suppressed menadione-induced inflammatory reaction in RBdSMCs. (A) Protein expression of myeloid differentiation primary response 88 (MyD88), MyD88, * vs. other groups with different symbols (†, ‡), p < 0.001. (B) Protein expression of TNF receptor associated factor 6 (TRAF6), * vs. other groups with different symbols (†, ‡), p < 0.001. (C) Protein expression of phosphorylated (p)-IKB-α, * vs. other groups with different symbols (†, ‡), p < 0.001. (D) Protein expression of nuclear factor-κB (NF-κB), * vs. other groups with different symbols (†, ‡), p < 0.001. (E) Protein expression of phosphorylated tumor necrosis factor alpha (TNF-α), * vs. other groups with different symbols (†, ‡), p < 0.001. (F) Protein expression of interleukin (IL)-1ß, * vs. other groups with different symbols (†, ‡), p < 0.001. (G) Protein expression of IL-6, * vs. other groups with different symbols (†, ‡), p < 0.001. (H) Protein expression of matrix metalloproteinase 9 (MMP-9), * vs. other groups with different symbols (†, ‡), p < 0.001. (I) Protein expression of induced nitric oxide synthase (iNOS), * vs. other groups with different symbols (†, ‡), p < 0.001. All statistical analyses were performed by one-way ANOVA, followed by Bonferroni multiple comparison post hoc test (n = 6 for each group). Symbols (*, †, ‡) indicate significance (at 0.05 level). ECSW = extracorporeal shock wave; RBdSMCs = rat bladder smooth muscle cells.