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. 2021 Oct 4;9(10):1391. doi: 10.3390/biomedicines9101391

Figure 8.

Figure 8

ECSW therapy reduced the ketamine-induced fibrosis and keratinization of urinary bladder by day 42 after ketamine administration. (A–D) Illustrating the immunohistochemical (IHC) microscopic finding (200×) for identification of IHC stained intensity of CK18 in urinary bladder epithelial layer (gray color). (E) Scoring intensity of CK18 positively-stained expression, * vs. other groups with different symbols (†, ‡, §), p < 0.0001. (F–I) Illustrating the Masson’s trichrome stain (200×) for identification of fibrosis area in urinary bladder muscle (blue color). (J) Analytical result of fibrotic area, * vs. other groups with different symbols (†, ‡, §), p < 0.0001. Scale bar in right lower corner represents 50 µm. All statistical analyses were performed by one-way ANOVA, followed by Bonferroni multiple comparison post hoc test (n = 6 for each group). Symbols (*, †, ‡, §) indicate significance (at 0.05 level). ECSW = extracorporeal shock wave.