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. Author manuscript; available in PMC: 2022 Jan 1.
Published in final edited form as: Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Oct 10;1866(1):158840. doi: 10.1016/j.bbalip.2020.158840

Figure 5. Proposed model for the implication of SCD5 activity in pathobiological mechanisms of disease.

Figure 5.

Excess SCD5 expression evokes a chronically greater ratio MUFA-to-SFA in cells, with consequent alterations in key metabolic and signaling pathways involved in cell proliferation, differentiation and survival. While the molecular mechanisms by which SCD5 is linked to developmental and neurological pathologies, as well as in and cancer, remain to be elucidated, human genetic data and experimental studies suggest that abnormal SCD5 may be implicated in the onset and progression of disease.