Table 4.

Study summaries using with HA for the treatment of inflammatory bowel disease.

Formulation		Studies	Administration Route	Main Results	Ref.
IBD98-M	Conjugate	Ex vivo and in vivo	Injected into the ligated area of the distal colon	Promotion of healing of the intestinal mucosa; reduction in intestinal inflammation	[140]
HANPs with BDS	Polymeric Nanoparticles	In vitro		Inflammation reduction	[141]
HA-KPV-NPs	Polymeric nanoparticles	In vitro and in vivo	Oral	Inflammation relief; mucosal healing; combination with hydrogel exhibits increased ability to prevent mucosal damage	[145]
HMWHA		In vitro and in vivo	Local application	Improvement in tissue regeneration	[146]
HMWHA		In vivo	Systemic	Relief of UC symptoms; increased expression of COX-2 and PGE2	[147]
HABN	Conjugate	In vivo	Oral	Colon epithelium barrier restored	[148]