Figure 2.

Spatial learning and memory in Active Allothetic Place Avoidance task across all age groups. Transgenic animals are marked in red; wild type animals in blue. Values are depicted as group averages, vertical bars indicate SEM. Statistically significant between-group differences are marked with an asterisk. (a) Distance in meters actively travelled in the AAPA arena as a measure of non-cognitive activity in the task. (b) Number of errors. Average number of entries into the punished sector of the arena per session. Transgenic rats made significantly higher amount of spatial errors at the age of 6–7 and 9–10 months, compared to the wild controls. (c) Maximal path avoidance. Transgenic subjects scored significantly shorter maximal distance avoided than the wild controls at the age of 6–7 months.