Figure 2.

Overview of preeclampsia symptoms triggered by AT1R-B2R. AT1R-B2R triggers major preeclampsia symptoms. Causality between increased AT1R-B2R protein complex formation and preeclampsia symptoms was documented in transgenic mice with smooth muscle-specific AT1R-B2R expression. AT1R-B2R could also cause preeclampsia symptoms in humans because preeclamptic pregnancies are characterized by increased vascular contents of AT1R-B2R aggregation. During the pathogenesis of preeclampsia, AT1R-B2R is activated by angiotensin II, mechanical stimulation and agonistic autoantibodies against AT1R.