Table 1.
Renal function parameters at day 116.
| Wild-Type | H4R−/− | STZ Wild-Type | STZ H4R−/− | |
|---|---|---|---|---|
| Urine volume (mL) | 1.33 ± 0.01 | 0.44 ± 0.10 * | 11.57 ± 0.91 * | 21.86 ± 1.84 °§ |
| pH # | 6.35 ± 0.16 | 6.5 ± 0.00 | 5.24 ± 0.03 * | 5.37 ± 0.09 ° |
| UPE (mg/24 h) | 3.85 ± 0.11 | 1.1 ± 0.22 * | 21.95 ± 1.63 * | 31.62 ± 2.94 °§ |
| Albumin excretion (µg/24 h) | 0.26 ± 0.04 | 0.09 ± 0.03 * | 0.91 ± 0.04 * | 0.31 ± 0.06 °§ |
| ACR (µg/mg) | 17.74 ± 1.63 | 8.67 ± 2.89 * | 267.38 ± 22.78 * | 56.92 ± 6.89 °§ |
| CrCl (mL/min) | 0.49 ± 0.12 | 0.28 ± 0.11 | 1.66 ± 0.19 * | 1.17 ± 0.75 |
# semi-quantitative analysis by dip-stick; UPE = urinary protein excretion; ACR = albumin-to-creatinine ratio; CrCl = creatinine clearance data are the mean ± S.E.M.; * p < 0.05 vs. wild-type; § p < 0.05 vs. STZ wild-type; ° p < 0.05 STZ H4R−/− vs. H4R−/−.