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. 2021 Oct 19;13(20):5248. doi: 10.3390/cancers13205248

Figure 3.

Figure 3

MYCN inhibition promotes cell cycle arrest at G0/G1 phase and induces apoptosis in RB cells. (A) Fraction of cells accumulated in each phase of the cell cycle after treatment with JQ1 and I-BET762 in Y79 and LRB1 cells. (B) Total apoptosis in Y79 and LRB1 cells treated with JQ1 and I-BET762. (C) Protein expression levels of MYCN, Bcl-2 and p53 upon inhibition with JQ1 and I-BET762 in Y79 and LRB1 cells. The error bars represent the standard error of mean (* p < 0.05 vs. untreated, *** p < 0.001 vs. untreated).