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. 2021 Oct 19;13(20):5248. doi: 10.3390/cancers13205248

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The effects of MYCN inhibition on cell migration in RB cells. (A) The bar graphs represent the top 4 downregulated genes involved in cellular migration and metastasis, upon MYCN knockdown in Y79 cells identified by microarray analysis (upper panel) and qRT-PCR validation of the identified genes (lower panel). (B) Reduced migration of cells was observed upon MYCN knockdown compared to the scrambled control cells. (C) Decreased gelatinolytic activity of active-MMP9 was observed in RB cells following MYCN inhibition. The error bars represent the standard error of mean.