Figure 5.

Histopathology of MT-2-luc xenografted tibias in treated and untreated mice. (A–C) In control mice, marked pathologic osteolysis characterized by eroded surfaces lined by active osteoclasts was seen. Marked necrosis was present throughout the marrow cavity. In AR-42-treated mice (D–F), bone tumors and osteolysis closely resembled those of the control mice. In Zol-treated mice (G–I), a marked decrease in eroded surfaces and bone loss with osteoblast activation and formation of intramedullary woven trabecular bone was present. Mice treated with both Zol, and AR-42 (J–L) had a similar phenotype as the Zol group.