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. 2021 Oct 8;12:737486. doi: 10.3389/fmicb.2021.737486

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Copyright © 2021 El-Mokhtar, Ramadan, Thabet, Abd-Elkader, Fouad, Sallam, Elgohary, Abd El-Hafeez, Mohamed and Sayed.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Determination of liver function parameters as a guide for HEV testing using receiver operating characteristic (ROC) curve. The ROC was plotted to identify the plasma ALT (A), R-value (B), and AST (C) threshold that differentiates between HEV suspected drug-induced liver injury (DILI) and non-HEV suspected DILI. (A) ROC curve for ALT showing the ALT threshold that differentiates between HEV and non-HEV cases. (B) ROC curve for R-value showing the R-value threshold that differentiates between HEV and non-HEV cases. (C) ROC curve for AST showing the AST threshold that differentiates between HEV and non-HEV cases.