TABLE 1.

Demographic and laboratory criteria and hepatitis E virus (HEV) and non-HEV suspected drug-induced liver injury (DILI).

	HEV suspected DILI N = 12	Non-HEV suspected DILI N = 68	Statisticsa S/NS
Age (years)	50 (40–64)	43 (32–52)	P = 0.09, NS
Sex (M/F) Ratio	7/5 1.4:1	38/30 1.26:1	P = 0.99, NS
ALT U/L	550 (458–847)	321 (280–394)	P < 0.0001, S
ALP U/L	290 (199–350)	314 (239–354)	P = 0.46, NS
R-valueb	6.6 (4.3–8.0)	2.96 (2.62–3.97)	P < 0.0001, S
AST U/L	462 (348–718)	274 (215–318)	P < 0.0001, S
Bilirubin (μmol/L)	143 (115–188)	134 (111–174)	P = 0.36, NS
Esinophilia (% positive)	3/12 (25%)	22/68 (32.3%)	P = 0.74, NS

All values are represented as medians and interquartile ranges. ALT: normal range < 40 U/L; AST: normal range < 35 U/L, and ALP: normal range, 46–115 U/L; bilirubin:

normal range 1.71 to 20.5 μmol/L.

S, significant; NS, non-significant.

^aStatistics was calculated using Mann–Whitney test.

^bR-value = (ALT/ULN)/(ALP/ULN). ULN is the upper limit of normal. The ULN of ALT and ALP was set as 40 and 115 U/L, respectively.