Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Oct 1;10(10):2630. doi: 10.3390/cells10102630

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Upper panel: Platelet granule secretion after stimulation with thrombin (concentrations: 0, 0.05, 0.1, 0.2, 0.5, and 1.0 U/mL) for the two brothers using flow cytometry. Severely impaired δ-granule secretion indicated by reduced platelet CD63 expression in P1 (A) and P2 (B) compared to the healthy control. Data are expressed as logarithmic arbitrary units (logAU) of anti-CD63-stained unstimulated and thrombin-stimulated platelets. Lower panel: Sanger Sequencing for confirmation of BLOC1S5:c.[113-1G > A];[113-1G > A]. Reverse chromatograms for patient P1 (C) and P2 (D).