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. 2021 Oct 15;11(10):396. doi: 10.3390/bios11100396

Figure 6.

Figure 6

Summary of recently developed electrochemical biosensors for the detection of oral cancer biomarkers in saliva (a) Sandwich-type immunosensor for the detection of interleukin 1β (IL-1β) in saliva through DPV. Reprinted with permission from ref. [111]. Copyright 2020 Elsevier. (b) Immunosensor for Cyfra21.1 detection based on a cysteamine and glutaraldehyde modified gold electrode. Reprinted with permission from ref. [112]. Copyright 2020 Elsevier. (c) Label-free immunosensor based on a modified ITO electrode for EIS detection of oral cancer biomarker in both saliva and serum. Reprinted with permission from ref. [119]. Copyright 2018 Elsevier (d) Magnetic beads-based sandwich immunoassay for the ampero-metric detection of HIF-1α. Reprinted with permission from ref. [115]. Copyright 2020 Elsevier. (e) Ratio-metric electrochemical DNA biosensor for the detection of ORAOV1 in saliva. Reprinted with permission from ref. [102]. Copyright 2018 Elsevier. (f) Multiplexed immunosensor based on dual SPCEs for the simultaneous detection of IL-1β and TNF-α. Reprinted with permission from ref. [130]. Copyright 2017 Elsevier. (g) SiNW sensor array for the multiplexed detection of TNF-α and IL-8. Reprinted with permission from ref. [107]. Copyright 2015 The Japan Society for Analytical Chemistry.