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Phenotypes and activated pathways characteristically observed in KRAS-dependent and independent KRAS mutant cancer cells. Abbreviations: KEAP1, Kelch-like ECH-associated protein 1; KRAS, v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog; LKB1, liver kinase B1; mTOR, mammalian target of rapamycin; NRF2, Nuclear factor erythroid 2-related factor 2; PI3K, Phosphatidylinositol 3-Kinase; RSK, Ribosomal S6 kinase; YAP, Yes-associated Protein 1.
