Figure 6.

BMP-7 decreases the expression of inflammatory dendritic cells (CD11b and CD11c) in the diabetic cardiac heart. (A,B) Representative photomicrographs of heart sections stained in the control group (a–e), STZ group (f–j), and STZ-BMP7 group (k–o) with sarcomeric-α actin (green, stained cardiac myocyte) (b, g, l) and CD11b (A) and CD11c (B) in red (a, f, k) with nuclei stained (c, h, m) by DAPI in blue, merged (d, i, n) and enlarged (e, j, o) image. (C,D) Quantitative analysis-derived histograms of CD11b (C) and CD11c (D) +ve cardiomyocytes (colocalization of both red and blue DAPI in green cardiomyocyte) were quantified over total DAPI in heart sections of mice. Statistical analysis was performed using One-Way ANOVA, which was followed by the Tukey test. Error bars= mean ± S.E.M., *** p < 0.001; Scale bar = 100 µm; n = 16/group.