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. 2021 Oct 14;11(10):1515. doi: 10.3390/biom11101515

Table 3.

Tetracyclic proline-based DKP.

Entry Structure Name Cell Line IC50 [μM] Reference
Tetracyclic
1. Inline graphic
34 		Drimentine G A2780 2.81 ± 0.09 [121]
1.38 ± 0.27 [121]
>10 [121]
1.01 ± 0.04 [121]
2.54 ± 0.18 [121]
2. Inline graphic
35 		Drimentine F BGC-823 >10 [121]
A549 >10 [121]
A2780 >10 [121]
3. Inline graphic
36 		Drimentine H Bel-7402 >10 [122]
BGC-823 >10 [122]
A549 >10 [122]
A2780 >10 [122]
4. Inline graphic
37 		Okaramine C L5178Y 14.7 [123]
5. Inline graphic
38 		Okaramine G L5178Y 12.8 [123]
6. Inline graphic
39–41 		Okaramine S (39) (R1 = R2 = prenyl)
Okaramine T (40) (R1 = prenyl, R2 = H)
Okaramine U (41) (R1 = R2 = H)		 (for 39) 0.78
22.4		 [124]
7 Inline graphic
42 		Roquefortine F A-549 14.0 [125]
HL-60 33.6 [125]
BEL-7402 13.0 [125]
MOLT-4 21.2 [125]
8. Inline graphic
43 		Roquefortine G A-549 42.5 [125]
HL-60 36.6 [125]
BEL-7402 >50 [125]
MOLT-4 >50 [125]
9. Inline graphic
44 		Fructigenine A MCF-7 >100, 63.1 1 [126]
K562 >100, 40.2 1 [126]
HL-60 >100, 47.7 1 [126]
10. Inline graphic
45 		Fructigenine B HeLa >100, 26.6 1 [126]
BGC-823 >100, 35.4 1 [126]
MCF-7 >100, 39.6 1 [126]
K562 >100,49.9 1 [126]
HL-60 >100, 34.2 1 [126]
11. Inline graphic
46 		Rugulosuvine A HeLa >100, 52.2 1 [126]
BGC-823 >100, 52.9 1 [126]
MCF-7 >100, 62.2 1 [126]
K562 >100, 75.6 1 [126]
HL-60 >100, 81.1 1 [126]
12. Inline graphic
Penicimutanin A (47)		 BGC-823 8.3, 88.0 1 [126]
MCF-7 7.3, 84.4 1 [126]
K562 10.7, 87.4 1 [126]
HL-60 6.1, 85.2 1 [126]
13. Inline graphic
Penicimutanin C (48)		 HeLa 8.6, 88.1 1 [126]
BGC-823 8.7, 83.9 1 [126]
MCF-7 6.0, 80.5 1 [126]
K562 11.9, 87.7 1 [126]
HL-60 5.0, 87.3 1 [126]
14. Inline graphic
49 		Eurotiumin A SF-268 >100 [127]
HepG2 >100 [127]
15. Inline graphic
50 		Eurotiumin B SF-268 >100 [127]
HepG2 >100 [127]

1 IR% values at 100 μg/mL.