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Chemical and structural properties of RNA that are usable for therapeutics. Different RNA types are shown as follow: (A) mRNA/modRNA. The uridine into pseudouridine substitution in modRNAs is represented by the greek Ψ symbol (red); (B) lncRNA; (C) circRNA. Locket (yellow) represents the covalently closed structure which makes circRNA resistant to exonucleases (RNases); (D) miRNA. See text for further details.
