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. 2021 Sep 23;10(10):2512. doi: 10.3390/cells10102512

Figure 3.

Figure 3

Examples of lncRNA circuitries in muscle regeneration. (A) In the cytoplasm, lncRNAs and circRNAs can act as competing endogenous RNAs (ceRNA) to interfere with miRNA binding to their targets. Examples include CAREL/mir-296 [161], MIAT/miR-24 [162], LncMUMA/miR-762 [163], Lnc-Mg/miR-125b [164], CircHipk3/miR-133a [165], CircNfix/miR-214 [166], HRCR/miR-233 [167], and Circ-miR/miR-132/212 [168]. In the nucleus, lncRNAs can influence gene expression at the epigenetic level through several mechanisms [65]. Examples in the figure include (B) lncRNA decoys: LncMAAT impedes SOX6 binding on the promoter of miR-29b to repress its transcription [169], Linc-YY1 binds YY1 and blocks its interaction with the PRC2 complex [170]; (C) lncRNA guides: CPR [171] and Lnc-Rewind [172] respectively interact with the DNMT3A and G9a repressive complexes and guide them on specific promoters. Dashed grey lines represent the loss of interaction and regulation. TF = Transcription Factor. See text for further details.