Table 1.
Summary of the studies investigating the role of BMPs in lens induction, lens fiber differentiation, gap junction-mediated communication, lens regeneration and cataract prevention in various experimental models.
| Author (Year) | Experimental Model | BMPs Investigated |
|---|---|---|
| Lens Induction | ||
| Luo et al. (1995) [27] | In vivo mouse | BMP-7 |
| Furuta et al. (1998) [83] | In vivo mouse | BMP-4 |
| Wawersik et al. (1999) [84] | In vivo mouse | BMP-7 |
| Zhao et al. (2002) [85] | In vivo mouse | BMP-7, noggin |
| Sjödal et al. (2007) [86] | In vivo chick | BMP-4 |
| French et al. (2009) [87] | In vivo zebrafish | BMP-4, GDF6a |
| Rajagopal et al. (2009) [88] | In vivo mouse | BMP receptor Acvr1 and Bmpr1a |
| Huang et al. (2015) [89] | In vivo chick, in vivo mouse | BMP-7, Acvr1, Bmpr1a |
| Lens Fiber Differentiation | ||
| Hung et al. (2002) [90] | In vivo mouse | BMP-7 |
| Faber et al. (2002) [91] | In vivo mouse | Bmpr1b |
| Belecky-Adams et al. (2002) [92] | In vivo chick | BMP-2, BMP-4, BMP-7, noggin |
| de Iongh et al. (2004) [93] | In vivo mouse, rat lenses | ActRIIA, ActRIIB, BmprII, ALK3 |
| Jarrin et al. (2004) [94] | In vivo chick | Noggin |
| Pan et al. (2006) [95] | In vivo mouse | BMP-4 |
| Boswell et al. (2008) [81] | In vitro embryonic chick | BMP-2, BMP-4, BMP-7, noggin |
| Rajagopal et al. (2009) [88] | In vivo mouse | BMP receptor Acvr1 |
| Pandit et al. (2011) [96] | In vitro in vivo chick | BMP-4 |
| Wiley et al. (2011) [97] | In vivo mouse | BMP receptor Acvr1 |
| Jidigam et al. (2015) [98] | In vivo chick | BMP-4, BMP-7 |
| Boswell et al. (2015) [99] | In vitro embryonic chick | BMP-2, BMP-4, BMP-7, noggin |
| Gap-junction Mediated Communication | ||
| Boswell et al. (2008) [100] | In vitro embryonic chick | BMP-2, BMP-4, BMP-7, noggin |
| Boswell et al. (2009) [101] | In vitro embryonic chick | BMP-4 |
| Lens Regeneration | ||
| Grogg et al. (2005) [102] | In vivo newt | BMP-4, BMP-7, chordin, Bmpr1a |
| Kurata et al. (2001) [103] | Xenopus | BMP-4 |
| Day and Beck (2011) [104] | Xenopus | Noggin, Nipsnap1 |
| Yang et al. (2010) [105] | Human embryonic stem cells | BMP-4, BMP-7, noggin |
| Cataract Prevention | ||
| Kowanetz et al. (2004) [106] | Mouse epithelial cell line | BMP-7, Id2, Id3 |
| Saika et al. (2006) [107] | In vivo mouse | BMP-7, Id2, Id3 |
| Shu et al. (2017) [108] | In vitro rat lens explant | BMP-7, Id2, Id3 |
| Shu et al. (2021) [109] | In vitro rat lens explant | BMP-4, ventromorphins |
| Du et al. (2021) [110] | HLE-B3 human lens cell line | BMP-4 |