Table 1.

UPS enzymes known to interact with the GRα.

Name	Type of UPS Enzyme	GRα Ligand-Binding Status	GRα Phosphorylation Status	Effect on GRα Protein Level	References
UbcH7	E2 conjugating enzyme	Liganded	Hyperphosphorylated	Reduce	[119]
TSG101	Inactive E2 conjugating enzyme	Unliganded	Hypophosphorylated	Stabilize	[111,120,121]
FBXW7α	E3 ligase (RING finger family) [122,123,124]	Liganded	Hyperphosphorylated	Reduce	[69,121,124,125,126]
CHIP		Ligand-independent	Phosphorylation-independent	Reduce	[112,124,127,128,129,130,131]
Mdm2/Hdm2		Ligand-independent but requires p53	Phosphorylation-independent	Reduce	[124,132,133,134,135,136]
Pellino-1		Liganded	Hyperphosphorylated	Reduce	[137]
UBR1		Unliganded	Hypophosphorylated	Reduce	[124,138,139]
RNF6		Ligand-independent	Phosphorylation-independent	Stabilize	[140]
Siah2		Ligand-independent	Hyperphosphorylated	Reduce	[141]