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. 2021 Oct 18;13(20):5214. doi: 10.3390/cancers13205214

Figure 1.

Figure 1

Evaluation of mitochondrial efficiency in MNCs isolated from CCS, and age-matched and elderly healthy controls. (A,B) reports the P/O value, obtained as the ratio between ATP synthesis and oxygen consumption, in the presence of pyruvate + malate or succinate, respectively, in MNCs isolated from: age-matched healthy controls (<10 y.o. n = 17; 11–20 y.o. n = 18; 21–40 y.o. n = 24), CCS of hematological tumors (<10 y.o. n = 26; 11–20 y.o. n = 33; 21–40 y.o. n = 30), CCS of solid tumors (<10 y.o. n = 22; 11–20 y.o. n = 29; 21–40 y.o. n = 10), adult healthy controls (n = 21; 41–60 y.o.), and elderly healthy control (61–80 y.o. n = 22 and > 80 y.o. n = 25). Statistical analysis was performed via non-parametric statistical approach (Mann–Whitney U test). *, **, ***, and **** indicate a p-value of p < 0.05, 0.01, 0.001, and 0.0001, respectively, between CCS samples and age-matched healthy controls. #, ##, ### and #### indicate a significant difference for p < 0.05, 0.01, 0.001, and 0.0001, respectively, between CCS samples and adult healthy controls (41–60 y.o.). No significant differences have been observed between CCS and elderly control (61–80, and >80 y.o.).