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. 2021 Oct 18;13(20):5214. doi: 10.3390/cancers13205214

Figure 4.

Figure 4

The glucose metabolism alterations were detectable in CCS after chemo/chemoradiotherapy but not after only bone marrow transplantation. The reported biochemical parameters were gathered from the MNCs isolated from hematological CCS patients treated with chemo/chemoradiotherapy (<20 y.o., n = 59), CCS patients treated only with bone marrow transplantation (BMT) (<20 y.o., n = 15), and the age-matched healthy subjects (n = 35). (A,B) reports the P/O value, obtained as the ratio between ATP synthesis and oxygen consumption, in the presence of pyruvate + malate or succinate, respectively. (C) shows the MDA level, as marker of lipid peroxidation. (D) reports the cellular energy status, expressed as the ATP/AMP ratio. (E) shows the LDH activity, as marker of anaerobic glycolysis. Statistical analysis was performed via non-parametric statistical approach (Mann–Whitney U test). **** indicates a p-value of p < 0.0001 between healthy samples and CCS patients treated with chemo/chemoradiotherapy. ## and #### indicate significant differences for p < 0.0001 between CCS patients treated with only BMT and CCS patients treated with chemo/chemoradiotherapy. No significant differences have been observed between healthy subjects and CCS patients treated with only BMT.