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. 2021 Oct 1;10(10):2610. doi: 10.3390/cells10102610

Figure 1.

Figure 1

(A) PV-positive cortical interneuron filled with biocytin labeled with streptavidin-conjugated AlexaFluor 488. Alterations in this subclass of interneurons are consistently reported in ASD. Scale bar: 50 μm. (B). Typical firing patter of PV interneurons in response to depolarizing current injection (100 pA for 500 ms). These neurons fire action potentials at a high frequency constantly for a prolonged period. The inter-spike intervals do not largely change during the prolonged spike train, i.e., fast-spiking. Calibration: 100 ms and 25 mV (from Reference [81] with edits).