Table 6.
Average Age of Onset.
| Disease | Mutation | Average Age of Onset |
|---|---|---|
| Familial Alzheimer’s Disease | A21G | 46.2 |
| Familial Alzheimer’s Disease | A42T | 63.0 |
| Familial Alzheimer’s Disease | D7N | 60.0 |
| Familial Alzheimer’s Disease | E22G | 57.5 |
| Cerebral Amyloid Angiopathy | D23N | 68.9 |
| Cerebral Amyloid Angiopathy | E22K | 55.0 |
| Cerebral Amyloid Angiopathy | E22Q | 55.0 |
| Cerebral Amyloid Angiopathy | L34V | 60.0 |
| Wildtype | WT | 65.0 |
These are the average age of onset for each of the mutations of Aβ used in the data set. The mutations that have an average age of onset less than 60 years were used for this analysis to predict the residues that aggregate faster.