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. 2021 Oct 1;10(10):2624. doi: 10.3390/cells10102624

Figure 1.

Figure 1

Components of the nucleus and the nuclear envelope involved in nuclear dynamics. Nesprin proteins are a component of the outer nuclear membrane (ONM) that interact with various cytoskeletal proteins in the cytosol. SUN proteins are components of the inner nuclear membrane (INM) and can interact with nesprin proteins to form the Linker of Nucleoskeleton and Cytoskeleton (LINC) complex, which is a structural and mechanical feature of the nuclear envelope. TorsinA is contained in the nuclear envelope lumen and can interact with LINC complexes and the INM protein LAP1. Proteins from the LEM domain family (LAP2β, Emerin, MAN1, LEMD2) are INM proteins that interact with Barrier to Autointegration Factor (BAF) to facilitate heterochromatin anchoring to the lamina. The nuclear lamina is a meshwork of intermediate filaments (A- and B-type lamins) that sits inside the INM and gives structural support to the nucleus. Lamin B Receptor (LBR) is another INM protein that can interact with heterochromatin through the linker protein HP1. Nuclear Pore Complexes span both nuclear membranes to provide transport between the nucleus and cytosol. Created with biorender.com (accessed on 1 September 2021).