Table 1.

Protein alterations affecting nuclear morphology.

Protein Alteration	Nuclear Changes	References
Lamins and Associated Proteins
Lamin A mutation	Lobulations	[68,69,70,71]
Lamin A truncation	Increased area, blebs, lobulations, aneuploidy	[72,73,74]
Lamin B1 truncation	Blebs	[74,75,76]
Lamin B2 deletion	Elongation	[76]
Lamin B2 deletion	Ruptures	[77]
Lamin A, B1 or B2 depletion	Decreased area	[78]
Lamin A, B1 or B2 overexpression	Increased area	[78]
Emerin mutation	Increased area	[79]
Emerin deletion	Increased area	[73]
Emerin depletion	Increased area, lobulations, blebs	[79,80]
Emerin depletion	Reduced area, invaginations	[81]
Emerin overexpression	Increased nuclear area	[82]
LEM2 depletion	Lobulations	[66]
LAP1 mutation	cytoplasmic channels, lobulations, invaginations	[83,84]
LAP1 deletion	Ruffled	[85]
LAP1 overexpression	Lobulations	[86]
LAP1C overexpression	Invaginations	[87]
LAP2b depletion	Increased area, hyperploidy	[67]
ANKLE2 depletion	Lobulations, increased area, hyperploidy	[55,63,65]
ZMPSTE24 mutation	Lobulations	[88,89]
LINC Complex Proteins
Nesprin 1 mutation	Lobulations	[90]
Nesprin 1 or Nesprin 2 depletion	Lobulations, increased area	[91,92]
SUN1 mutation	Enhance blebs in Lamin A mutant cells	[93]
SUN1/SUN2 depletion	Lobulations	[94,95]
SUN2 overexpression	Lobulations	[96]
Torsin deletion	Intraluminal blebs	[97,98]
Torsin 1 overexpression	Blebs, invaginations	[99]
Chromatin Enzymes
BRG1 depletion	Lobulations	[100]
BRG1-ATPase deficient	Increased area	[101]
ARID1A	Increased area	[102]
RING1B depletion	Increased area, hyperploidy	[103]
MOF deletion	Blebs, micronuclei	[104]
NCAPH2 or NCAPD3 depletion	Lobulations, increased area	[105]
SMC2 depletion	Lobulations	[105]
Nucleosome Proteins
mH2A1 and mH2A2 deletion	Lobulations, blebs, increased area	[106,107]
HMGN5 overexpression	Blebs	[108]
Nuclear Pore-Related Proteins
ELYS depletion	Decreased size	[109]
KPNA7 depletion	Lobulations	[110]
NUP53 depletion	Lobulations	[111]
NUP98 depletion	Lobulations	[111,112]
NUP153 depletion	Lobulations, invaginations	[113]
Cytoskeletal-Associated Proteins
Cofilin and ADF depletion	Lobulations	[114]
DIAPH3 depletion	Lobulations	[80]
a-dystrobrevin depletion	Lobulations, blebs, septa	[115]
EPB41 depletion	Blebs, lobulations	[116]
LLGL1 or LLGL2 depletion	Increased area	[117]
PPP1R12A or PPP1CB depletion	Lobulations, blebs	[118]
Other
GATA6 decrease	Larger size, lobulations, aneuploidy	[119]
NOP53 depletion	Lobulations	[120]
Nucleophosmin depletion	Lobulations	[121]
SIRT2 depletion	Increased area	[65]
SPANX depletion	Increased area, lobulations	[122]
STIP1 depletion	Reduced size, invaginations	[81]
TMEM170A depletion	Increased area, lobulations	[123]
YBX1 depletion	Lobulations	[124]