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. 2021 Oct 15;11(10):1519. doi: 10.3390/biom11101519

Figure 3.

Figure 3

Depletion of PDGFRβ-lineage cells in mdx mice. (A) A snapshot of the treadmill test revealing increased endurance of mdx/Pdgfrb-TK mice treated with GCV compared to control (PBS) treatment. (B) Long-term endurance improvement in mdx/PDGFRb-TK mice treated with GCV. * p < 0.05, n = 4 (Student’s t-test). (C) Long-term grip strength improvement in mdx/PDGFRb-TK mice treated with GCV. * p < 0.05, n = 4 (Student’s t-test). (D) Timeline of experiment showing endurance improvement in mdx/Pdgfrb-TK mice treated with GCV. (E) Masson’s trichrome staining showing decreased regression and disorganization of myofibers and reduced fibrosis in muscle of mdx/Pdgfrb-TK mice treated with GCV. (F) Quantification of Masson’s trichrome staining-positive area in gastrocnemius, diaphragm, and cardiac muscle, n > 15. Scale bar: 50 µm.