Figure 2.

Genomic aberrations found by SNPa in MYCN amplified cases (MNA) with intra-tumour heterogeneity (ITH) (A) and non-ITH (B). In the upper part of both Figures A and B the analysed samples (T: solid tumour -1,2-; LB: liquid biopsy) corresponding to each case (33–52) with the total number of segmental chromosomal aberrations (SCAs) and the typical ones in parenthesis, are shown. In Figure 2A the total number of SCAs and typical ones of each case, taking into account all the analysed samples, are also presented. Solid blue or red squares refers to gains or losses, respectively, in the indicated chromosome arm. Gradient color from blue or red to black indicates gains or losses with two or more chromosome fragments in the chromosome arm. Solid yellow squares indicate the presence of a chromotripsis-like phenomenon, and gradient color from yellow to blue refers to chromotripsis-like phenomenon within a gain. Purple squares indicate that the samples have been analysed for mutations and amplifications in ALK gene; NA: in the squares indicates that any aberration has been detected in the sample; A: referes to presence of ALK amplification; M: indicates ALK mutation. O: indicates amplification of any gene or region in the chromosome arm, excluding MYCN or ALK amplification.