Figure 3.

Genomic aberrations found by SNPa in cases with heterogeneous MYCN amplification (hetMNA). In the upper part the number of the analysed samples (T: solid tumour -1, 2, 3-; LB: liquid biopsy) corresponding to each case (53–58) with the total number of SCAs and the typical ones in parenthesis, are shown. Solid blue or red squares refers to gains or losses, respectively in the indicated chromosome arm. Gradient color from blue or red to black indicates gains or losses with 2 or more chromosome fragments in the chromosome arm. Gradient color from blue to red refers to both gains and losses in the same chromosome arm of a sample. Solid yellow squares indicate presence of chromotripsis-like phenomenon. Green squares indicate MYCN amplification detection by SNPa. Black squares indicate presence of focal segmental chromosomal aberrations (FSCAs) affecting TERT or ATRX genes. Purple squares indicate that the samples have been analysed for alternative lengthening of telomeres (ALT) or for mutations and amplifications in ALK gene; NA: in the squares indicates that any aberration has been detected in the sample.