Table 6.
Association between enhancer and insulator HPSE gene SNPs and relative heparanase mRNA expression level among healthy individuals.
| SNPs | Location | Genotype | No. | mRNA Level | Comparisons to Carriers | p Value |
|---|---|---|---|---|---|---|
| (AV ± SE) | ||||||
| rs4693608 | Enhancer | AA | 27 | 13.9 ± 2.3 | AA to GG | 0.01 |
| AG | 62 | 11.7 ± 1.6 | AA to others | 0.2 | ||
| GG | 19 | 7.2 ± 1.1 | GG to others | 0.0028 | ||
| rs4426765 | Insulator | AA | 59 | 13 ± 1.7 | AA to CC | 0.56 |
| AC | 36 | 9.3 ± 1.4 | AA to others | 0.14 | ||
| CC | 12 | 11.3 ± 2.2 | CC to others | 0.91 | ||
| rs28649799 | Insulator | AA | 84 | 11.4 ± 1.2 | AA to AG | 0.73 |
| AG | 22 | 12.5 ± 2.8 | ||||
| rs4364254 | Insulator | TT | 49 | 12.7 ± 1.8 | TT to CC | 0.0029 |
| TC | 50 | 11.3 ± 1.5 | TT to others | 0.32 | ||
| CC | 9 | 6.1 ± 1 | CC to others | 0.00049 | ||
| rs4693608 & rs4364254 | Enhancer & Insulator | HR | 25 | 14.6 ± 2.4 | HR to LR | 0.007 |
| MR | 59 | 11.9 ± 1.7 | HR to others | 0.16 | ||
| LR | 22 | 7.1 ± 0.9 | LR to others | 0.00098 | ||
| rs4693608 & rs4364254 & rs4426765 | Enhancer & Insulator | N-HR | 35 | 14. 7 ± 2.3 | N-HR to N-LR | 0.0014 |
| N-MR | 55 | 11.1 ± 1.5 | N-HR to others | 0.082 | ||
| N-LR | 16 | 6.4 ± 0.7 | N-LR to others | 0.000076 |
AV—average; SE—standard error (SE = SD/√N, SD—standard deviation). Significant deviations (p < 0.05) are marked in bold.