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. 2021 Sep 29;10(10):2586. doi: 10.3390/cells10102586

Figure 1.

Figure 1

Hypothesized mechanism of mitochondrial permeability transition (MPT)-induced skeletal muscle atrophy. In this scheme, MPT causes atrophy by recruiting previously established mechanisms of muscle atrophy involving caspase 3 activation and mitochondrial ROS-induced upregulation of atrogenes and autophagy genes. This figure was created using Biorender.com.