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. 2021 Sep 29;10(10):2586. doi: 10.3390/cells10102586

Figure 5.

Figure 5

To determine if inhibition of mROS or caspase-3 prevents MPT-induced muscle fiber atrophy, isolated mouse FDB muscle fibers were treated with 300 nM Bz423 (MPT-inducer) or 300 nM Bz423 and either 5 µM mitoTEMPO (mROS-inhibitor) or 20 µM Ac-ATS010-KE (caspase-3-inhibitor). Both inhibition of mROS and caspase-3 prevented MPT-induced reduction in myofiber diameter. Biological replicates (n = 2) are identified by data points of different colors within a given treatment, while technical replicates share the same color data point. *** p < 0.001 versus Day 0.