Table 2.

Effects of antidepressant drugs on Kir4.1 function/expression.

Reference	Drug	Model	Kir4.1 Expression/Function
Su et al., 2007 [44]	TCAs	HEK293T cells	↓ Kir4.1
Ohno et al., 2007 [45]	SSRIs	HEK293T cells	↓ Kir4.1
Furutani et al., 2009 [52]	TCAs and SSRIs	Chimeric and site directed mutants of Kir4.1 expressed in Xenopus Laevis oocytes and computational analyses of three-dimensional arrangements of the ligands.	↓ Kir4.1 interacting with channel pore residues
Kinboshi et al., 2017 [53]	SSRIs, TCAs, mianserin, and siRNA	Primary mouse astrocytes	↓ Kir4.1 and ↑ BDNF
Stenovec et al., 2020 [46]	Ketamine	Rat cortex astrocytes	↓ Kir4.1 reducing mobility of Kir4.1-carrying vesicles.
Song et al., 2019 [51] and Song et al., 2021 [50]	Fluoxetine	Normal adult rats	↓ Kir4.1 and ↑ BDNF

TCAs: tricyclic antidepressants; SSRIs: selective serotonin reuptake inhibitors, siRNA: RNA silencing; BDNF: brain derived neurotrophic factor.