Table 3.

CIC distribution in primary lesions and metastases.

Cancer Type	CIC Distribution	Ref
Head and neck squamous cell carcinoma	Lymph nodes metastases, the average CIC numbers were significantly lower than in the corresponding primary tumors	[89]
Head and neck squamous cell carcinoma	In the central tumor area, the average value of CIC structures was higher than in the invasive front	[88,89]
Pancreatic ductal adenocarcinoma	CIC positivity was significantly more prevalent in liver metastases	[16]